The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 02, 2025

Filed:

Sep. 08, 2022
Applicant:

The Texas A&m University System, College Station, TX (US);

Inventors:

Elizabeth Sally Ward Ober, Southampton, GB;

Venkata Siva Charan Devanaboyina, College Station, TX (US);

Raimund Johannes Ober, Southampton, GB;

Assignee:

The Texas A&M University System, College Station, TX (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01); C07K 14/71 (2006.01); A61K 51/10 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2881 (2013.01); A61K 39/00 (2013.01); A61K 39/0011 (2013.01); C07K 14/71 (2013.01); A61K 38/00 (2013.01); A61K 51/1027 (2013.01); C07K 2317/52 (2013.01); C07K 2317/569 (2013.01); C07K 2317/71 (2013.01); C07K 2317/72 (2013.01); C07K 2317/76 (2013.01); C07K 2317/77 (2013.01); C07K 2317/92 (2013.01); C07K 2319/30 (2013.01);
Abstract

The present disclosure includes a fusion protein, called a 'Seldeg', including a targeting component that specifically binds to a cell surface receptor or other cell surface molecule at near-neutral pH, and an antigen component fused directly or indirectly to the targeting component. The antigen component is configured to specifically bind a target antigen-specific antibody. The present disclosure also includes a method of depleting a target antigen-specific antibody from a patient by administering to the patient a Seldeg having an antigen component configured to specifically bind the target antigen-specific antibody.


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