The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 02, 2025
Filed:
Feb. 08, 2024
Applicant:
Paq Therapeutics Inc., Burlington, MA (US);
Assignee:
PAQ Therapeutics Inc., Burlington, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 519/00 (2006.01); A61K 31/519 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
C07D 519/00 (2013.01); A61K 31/519 (2013.01);
Abstract
Provided herein are KRAS G12D proteolysis targeting chimeras (PROTACs), compositions comprising the KRAS G12D PROTACs, and methods of making and using the KRAS G12D PROTACs, e.g., to promote degradation of KRAS G12D and/or treat KRAS G12D-associated cancers. In an embodiment, the KRAS G12D PROTAC has the following structural formula:[KRAS G12Di]-L'-[Degron],or a pharmaceutically acceptable salt thereof, wherein values for the variables (e.g., KRAS G12Di, L′, Degron) are as described herein.