The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 02, 2025
Filed:
Jun. 25, 2021
Zhejiang University, Hangzhou, CN;
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, CN;
Rong Sheng, Hangzhou, CN;
Jia Li, Shanghai, CN;
Dongyan Gu, Hangzhou, CN;
Yubo Zhou, Shanghai, CN;
Jun Wei, Hangzhou, CN;
Mengmeng Zhang, Shanghai, CN;
Yongzhou Hu, Hangzhou, CN;
Kaixiang Zhang, Shanghai, CN;
Jieyu Liu, Shanghai, CN;
Weijuan Kan, Shanghai, CN;
ZHEJIANG UNIVERSITY, Hangzhou, CN;
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES, Shanghai, CN;
Abstract
Provided by the present disclosure are an amino quinazolinone and amino isoquinolone derivatives. It is verified by numerous experiments that the compounds provided by the present disclosure have good inhibiting effects on PI3Kα and PI3Kγ, most of the compounds have prominent inhibiting effect on PI3Kα, and show strong growth inhibiting effect on PIK3CA mutant tumor cells such as human breast cancer cell strain (MCF7). Therefore, the amino quinazolinone and amino isoquinolone derivatives according to the present disclosure can be applied in the preparation of anti-tumor and anti-inflammatory medicines, and can be used as PI3Kα inhibitors in the preparation of medicines for treatment of human or animal cell proliferation related tumors, the medicines comprising the derivatives any one or more of pharmaceutically acceptable salts and solvates thereof as well as pharmaceutically acceptable carriers. Formulas a and b are shown as below: