The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 02, 2025
Filed:
Oct. 25, 2019
Jilin Asymchem Pharmaceuticals Co., Ltd., Jilin, CN;
Hao Hong, Morrisville, NC (US);
Enxuan Zhang, Tianjin, CN;
Jiangping Lu, Tianjin, CN;
Fuliang Wei, Tianjin, CN;
Guanda Che, Tianjin, CN;
Mingjie Feng, Tianjin, CN;
JILIN ASYMCHEM PHARMACEUTICALS CO., LTD., Jilin, CN;
Abstract
A preparation method for a trans-cyclobutane-o-dicarboxylic acid ester and a derivative thereof includes the following steps: in an organic solvent, catalyzing a substrate with a structure as shown in a structural formula I by using organic alkali at 50-90° C. so as to generate isomerization, acquiring the trans-cyclobutane-o-dicarboxylic acid ester or the derivative thereof, herein the structural formula I is as follows: Each R, R, Rand Ris independently one of hydrogen or an alkyl of C-C, and each of Rand Ris independently one of alkyl of C-Cand benzyl.