The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 02, 2025

Filed:

Jun. 24, 2022
Applicant:

University of Louisville Research Foundation, Inc., Louisville, KY (US);

Inventors:

Ori Braun, Palo Alto, CA (US);

Martin G. O'toole, Louisville, KY (US);

Shlomit Schaal, Louisville, KY (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/00 (2006.01); A61K 9/08 (2006.01); A61K 31/7016 (2006.01); A61K 47/26 (2006.01); A61P 27/02 (2006.01);
U.S. Cl.
CPC ...
A61K 9/0048 (2013.01); A61K 9/0051 (2013.01); A61K 9/08 (2013.01); A61K 31/7016 (2013.01); A61K 47/26 (2013.01); A61P 27/02 (2018.01);
Abstract

Methods of reducing oxidative damage to an eye of a subject are provided. Aspects of the method include intravitreal injection an antioxidant composition consisting essentially of a non-reducing sugar or a hydrate thereof. In some embodiments, the non-reducing sugar is trehalose. The methods can further include surgical removal of at least a portion of the subject's vitreous humor during a vitrectomy. Also provided are ophthalmic compositions, kits and pre-loaded injection devices for use in vitrectomy surgery which find use in the subject methods.


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