The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 02, 2025

Filed:

Nov. 12, 2019
Applicants:

The Broad Institute, Inc., Cambridge, MA (US);

Massachusetts Institute of Technology, Cambridge, MA (US);

Yale University, New Haven, CT (US);

Inventors:

Aviv Regev, Cambridge, MA (US);

Piotr Bielecki, New Haven, CT (US);

Richard Flavell, New Haven, CT (US);

Monika Kowalczyk, Cambridge, MA (US);

Samantha Riesenfeld, Cambridge, MA (US);

Jan-Christian Huetter, Cambridge, MA (US);

Elena Torlai Triglia, Cambridge, MA (US);

Assignees:

The Broad Institute, Inc., Cambridge, MA (US);

Massachusetts Institute of Technology, Cambridge, MA (US);

Yale University, New Haven, CT (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/22 (2006.01); A01K 67/0278 (2024.01); A61K 38/20 (2006.01); A61K 40/10 (2025.01); A61K 40/22 (2025.01); A61K 40/41 (2025.01); C12N 15/10 (2006.01); C12N 15/113 (2010.01); C12Q 1/6881 (2018.01); G01N 33/50 (2006.01); G01N 33/569 (2006.01); A61K 48/00 (2006.01); C12N 5/078 (2010.01); C12N 9/22 (2006.01); C12N 15/115 (2010.01); C12N 15/85 (2006.01); C12N 15/90 (2006.01);
U.S. Cl.
CPC ...
A01K 67/0278 (2013.01); A61K 38/20 (2013.01); A61K 40/10 (2025.01); A61K 40/22 (2025.01); A61K 40/416 (2025.01); C12N 15/102 (2013.01); C12N 15/113 (2013.01); C12Q 1/6881 (2013.01); G01N 33/5047 (2013.01); G01N 33/56972 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0325 (2013.01); A01K 2267/0368 (2013.01); A01K 2267/0387 (2013.01); A61K 48/00 (2013.01); A61K 2239/31 (2023.05); A61K 2239/38 (2023.05); C12N 5/0634 (2013.01); C12N 9/22 (2013.01); C12N 15/115 (2013.01); C12N 15/85 (2013.01); C12N 15/907 (2013.01); C12Q 2600/158 (2013.01);
Abstract

The subject matter disclosed herein is generally directed to methods and compositions for modulating inflammation driven by differentiation of quiescent tissue-resident ILCs into a spectrum of pathogenic effectors. The subject matter disclosed herein is also generally directed to detecting and monitoring an ILC response. Additionally, the subject matter is directed to treating skin inflammation, such as psoriasis.


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