The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 26, 2025
Filed:
May. 28, 2021
Korea Research Institute of Chemical Technology, Daejeon, KR;
Seoul National University R&db Foundation, Seoul, KR;
Sun-Hyun Park, Daejeon, KR;
Ki-Suk Kim, Daejeon, KR;
Jae-Meun Lee, Daejeon, KR;
Jae-Hyeok Lee, Daejeon, KR;
Seong-Hoon Park, Daejeon, KR;
Ji Yeoun Lee, Seoul, KR;
Jinju Park, Seoul, KR;
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY, Daejeon, KR;
SEOUL NATIONAL UNIVERSITY R&DBFOUNDATION, Seoul, KR;
Abstract
A clearing pretreatment method of a biological sample having a size of at most 1 mm, that is, a spheroid or organoid, according to the present invention uses a phosphate-buffered saline (PBS) rather than a conventional sucrose solution as a pretreatment solution, thus solving the problem in which the spheroid or organoid floats above the surface of water due to the density difference such that the structure of the sample is damaged. Therefore, there is an effect in that the spheroid or organoid can be transparentized while maintaining the original shape thereof, thus making it possible to image deep parts.