The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 26, 2025
Filed:
Sep. 12, 2019
Applicant:
Fred Hutchinson Cancer Center, Seattle, WA (US);
Inventors:
Hans-Peter Kiem, Seattle, WA (US);
Olivier Humbert, Seattle, WA (US);
Roland B. Walter, Seattle, WA (US);
Assignee:
Fred Hutchinson Cancer Center, Seattle, WA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/13 (2006.01); A61K 31/7088 (2006.01); A61K 35/28 (2015.01); A61K 39/395 (2006.01); A61K 47/68 (2017.01); A61P 37/04 (2006.01); C07K 16/28 (2006.01); C12N 15/113 (2010.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
C12N 15/86 (2013.01); A61K 31/7088 (2013.01); A61K 35/28 (2013.01); A61K 39/3955 (2013.01); A61K 47/6849 (2017.08); A61P 37/04 (2018.01); C07K 16/2803 (2013.01); C12N 15/1138 (2013.01); C07K 2317/31 (2013.01); C07K 2317/565 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C07K 2319/30 (2013.01); C07K 2319/33 (2013.01); C12N 2310/122 (2013.01); C12N 2310/14 (2013.01); C12N 2310/531 (2013.01); C12N 2320/31 (2013.01); C12N 2740/15043 (2013.01);
Abstract
Systems and methods to selectively protect therapeutic cells by reducing CD33 expression in the therapeutic cells and targeting non-therapeutic cells with an anti-CD33 therapy. The selective protection results in the enrichment of the therapeutic cells while simultaneously targeting any diseased, malignant and/or non-therapeutic CD33 expressing cells within a subject.