The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 26, 2025
Filed:
Jan. 02, 2019
Applicant:
President and Fellows of Harvard College, Cambridge, MA (US);
Inventors:
David R. Liu, Lexington, MA (US);
Jacob Charles Carlson, Somerville, MA (US);
Ahmed Hussein Badran, Somerville, MA (US);
Kevin Michael Esvelt, Cambridge, MA (US);
Assignee:
President and Fellows of Harvard College, Cambridge, MA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 15/10 (2006.01); C12N 7/00 (2006.01); C12N 15/01 (2006.01); C12N 15/64 (2006.01); C12N 15/70 (2006.01); C40B 10/00 (2006.01); C40B 50/06 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1058 (2013.01); C12N 7/00 (2013.01); C12N 15/01 (2013.01); C12N 15/1024 (2013.01); C12N 15/1037 (2013.01); C12N 15/1086 (2013.01); C40B 10/00 (2013.01); C40B 50/06 (2013.01); C07K 2319/735 (2013.01); C07K 2319/80 (2013.01); C07K 2319/81 (2013.01); C12N 15/64 (2013.01); C12N 15/70 (2013.01); C12N 2795/00041 (2013.01); C12N 2795/14121 (2013.01); C12N 2795/14152 (2013.01); C12N 2800/101 (2013.01); C12N 2800/40 (2013.01); C12N 2830/002 (2013.01); C12N 2830/60 (2013.01);
Abstract
Strategies, systems, methods, reagents, and kits for phage-assisted continuous evolution are provided herein. These include strategies, systems, methods, reagents, and kits allowing for stringency modulation to evolve weakly active or inactive biomolecule variants, negative selection of undesired properties, and/or positive selection of desired properties.