The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 26, 2025
Filed:
Jan. 24, 2023
Applicant:
Autolus Limited, London, GB;
Inventors:
Martin Pulé, London, GB;
Shaun Cordoba, London, GB;
Shimobi Onuoha, London, GB;
Simon Thomas, London, GB;
Assignee:
AUTOLUS LIMITED, London, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/705 (2006.01); A61K 35/00 (2006.01); A61K 38/17 (2006.01); A61K 39/00 (2006.01); A61K 40/11 (2025.01); A61K 40/31 (2025.01); A61K 40/42 (2025.01); C07K 14/725 (2006.01); C07K 14/735 (2006.01); C07K 16/28 (2006.01); C07K 16/30 (2006.01); C12N 5/0783 (2010.01);
U.S. Cl.
CPC ...
C07K 14/70521 (2013.01); A61K 38/1774 (2013.01); A61K 40/11 (2025.01); A61K 40/31 (2025.01); A61K 40/4211 (2025.01); A61K 40/4212 (2025.01); C07K 14/7051 (2013.01); C07K 14/70535 (2013.01); C07K 16/2803 (2013.01); C07K 16/2863 (2013.01); C07K 16/3061 (2013.01); C12N 5/0636 (2013.01); C12N 5/0638 (2013.01); A61K 35/00 (2013.01); A61K 2039/505 (2013.01); C07K 2317/31 (2013.01); C07K 2317/622 (2013.01); C07K 2319/03 (2013.01); C07K 2319/74 (2013.01); C12N 2501/505 (2013.01); C12N 2501/599 (2013.01); C12N 2510/02 (2013.01);
Abstract
The present invention provides a cell which co-expresses a first chimeric antigen receptor (CAR) and second CAR at the cell surface, each CAR comprising an antigen-binding domain, wherein the antigen-binding domain of the first CAR binds to CD19 and the antigen-binding domain of the second CAR binds to CD22.