The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 26, 2025
Filed:
Aug. 10, 2018
Applicants:
Fred Hutchinson Cancer Center, Seattle, WA (US);
University of Washington, Seattle, WA (US);
Inventors:
Joshua Veatch, Seattle, WA (US);
Stanley R. Riddell, Sammamish, WA (US);
Sylvia Lee, Seattle, WA (US);
Assignees:
FRED HUTCHINSON CANCER CENTER, Seattle, WA (US);
UNIVERSITY OF WASHINGTON, Seattle, WA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); A61K 35/17 (2015.01); A61K 40/11 (2025.01); A61K 40/32 (2025.01); A61K 40/42 (2025.01); A61P 35/00 (2006.01); C07K 14/725 (2006.01); C12N 5/0783 (2010.01); C12N 7/00 (2006.01); C12N 15/86 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/7051 (2013.01); A61K 35/17 (2013.01); A61K 40/11 (2025.01); A61K 40/32 (2025.01); A61K 40/4251 (2025.01); A61P 35/00 (2018.01); C12N 5/0636 (2013.01); C12N 7/00 (2013.01); C12N 15/86 (2013.01); A61K 38/00 (2013.01); A61K 2239/57 (2023.05); C12N 2740/10043 (2013.01);
Abstract
The present disclosure provides binding proteins, such as TCRs, that specifically bind various tumor associated antigens (including human BRAFV600E epitope), cells expressing such antigen specific binding proteins, nucleic acids encoding the same, and compositions for use in treating diseases or disorders in which cells express BRAFV600E, such as in cancer.