The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 26, 2025
Filed:
May. 10, 2024
Glaxosmithkline Intellectual Property (No.4) Limited, Stevenage, GB;
Ideaya Biosciences, Inc., South San Francisco, CA (US);
Janos Botyanszki, Norristown, PA (US);
Kevin Duffy, Phoenixville, PA (US);
Young Eun Choi, Cambridge, MA (US);
Claire L. Neilan, South San Francisco, CA (US);
Marcus M. Fischer, South San Francisco, CA (US);
GlaxoSmithKline Intellectual Property (No. 4) Limited, Stevenage, GB;
IDEAYA Biosciences, Inc., South San Francisco, CA (US);
Abstract
Disclosed herein are compounds of Formula (I): that inhibit DNA Polymerase Theta (Polθ) activity, in particular inhibit Polθ activity by inhibiting ATP dependent helicase domain activity of Polθ. Also, disclosed are pharmaceutical compositions comprising such compounds and methods of treating and/or preventing diseases treatable by inhibition of Polθ such as cancer, including homologous recombination (HR) deficient cancers.