The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 26, 2025
Filed:
Nov. 12, 2020
Bayer Aktiengesellschaft, Leverkusen, DE;
The Broad Institute, Inc., Cambridge, MA (US);
Daniel Meibom, Wuppertal, DE;
Yolanda Cancho Grande, Leverkusen, DE;
Pierre Wasnaire, Düsseldorf, DE;
Sarah Anna Liesa Johannes, Hilden, DE;
Kristin Beyer, Hilden, DE;
Till Freudenberger, Velbert, DE;
Damian Brockschnieder, Haan, DE;
Dmitry Zubov, Remscheid, DE;
Dzianis Menshykau, Düsseldorf, DE;
Tanja Krainz, Cambridge, MA (US);
Bryan Macdonald, Cambridge, MA (US);
Yi Xing, Cambridge, MA (US);
Nadine Elowe, Cambridge, MA (US);
Guzman Sanchez, Murcia, ES;
BAYER AKTIENGESELLSCHAFT, Leverkusen, DE;
THE BROAD INSTITUTE, INC., Cambridge, MA (US);
Abstract
The application relates to substituted hydantoinamides of formula (I) as ADAMTS7 antagonists, to processes for their preparation, their use alone or in combination for the treatment or prophylaxis of diseases, in particular of cardiovascular diseases, including atherosclerosis, coronary artery disease (CAD), peripheral vascular disease (PAD), arterial occlusive disease or restenosis after angioplasty. Ris hydrogen, alkyl, cycloalkyl, heterocycloalkyl, heteroaryl or phenyl; Ris hydrogen, cyano, halogen, alkylsulfonyl, alkyl, cycloalkyl or alkoxy; R, R, R, R, Rand Rare independently hydrogen, halogen, alkyl or alkoxy; most groups being optionally substituted; with the proviso that at least one of R, R, Ris H; X, X, X, X, Xand Xare independently N or C; with the proviso that in each ring maximal one X is N.