The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 26, 2025

Filed:

Dec. 20, 2019
Applicant:

Auransa Inc., Palo Alto, CA (US);

Inventors:

Gregory R. Luedtke, Salinas, CA (US);

Andrew Asher Protter, Palo Alto, CA (US);

Anna Halberg, Palo Alto, CA (US);

Pek Yee Lum, Palo Alto, CA (US);

Rajaa Sukhun, Palo Alto, CA (US);

Sidney Paul Elmer, Palo Alto, CA (US);

Hak Jin Chang, Harvard, MA (US);

Assignee:
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 213/81 (2006.01); A61P 35/00 (2006.01); C07C 251/24 (2006.01);
U.S. Cl.
CPC ...
C07D 213/81 (2013.01); A61P 35/00 (2018.01); C07C 251/24 (2013.01);
Abstract

The present disclosure provides a group of aromatic (e.g., pyridinyl, pyrimidinyl, pyrazinyl, or phenyl) diamidine analogs and pharmaceutically acceptable salts that are useful for treating a proliferative disease. The proliferative disease may include solid cancer or blood cancer. Compositions, methods of synthesizing the same and methods for treating various cancer using the analogs are disclosed herein. The present disclosure also provides pharmaceutical formulations comprising at least one of the compounds with a pharmaceutically acceptable carrier, diluent or excipient therefor.


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