The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 26, 2025
Filed:
May. 04, 2021
Synaffix B.v., Oss, NL;
Maria Antonia Wijdeven, Wijchen, NL;
Jorge Merijn Mathieu Verkade, Eindhoven, NL;
Jorin Hoogenboom, Wageningen, NL;
Sander Sebastiaan Van Berkel, Wijchen, NL;
Floris Louis Van Delft, Nijmegen, NL;
Petrus Josephus Jacobus Maria Van De Sande, Eindhoven, NL;
Synaffix B.V., Oss, NL;
Abstract
The present invention concerns antibody-conjugate having general structure (2):AB-[(L)-{Z—(L)—(L)—(L)—(L)-D}] (2)wherein AB is an antibody capable of targeting Trop-2-expressing tumours and D is selected from the group consisting of taxanes, anthracyclines, camptothecins, epothilones, mytomycins, combretastatins, vinca alkaloids, maytansinoids, enediynes such as calicheamicins, duocarmycins, tubulysins, amatoxins, bleomycins, dolastatins and auristatins, pyrrolobenzodiazepine dimers, indolinobenzodiazepine dimers, radioisotopes, therapeutic proteins and peptides (or fragments thereof), kinase inhibitors, MEK inhibitors, KSP inhibitors, and analogues or prodrugs thereof. These antibody-conjugates exhibit an improved therapeutic index. The invention further concerns a process for preparing the antibody-conjugate according to the invention, a method for targeting Trop-2-expressing cells, medical uses of the antibody-conjugates according to the invention.