The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 26, 2025
Filed:
Jun. 26, 2019
Tsrl, Inc., Ann Arbor, MI (US);
Regents of the University of Michigan, Ann Arbor, MI (US);
Elke Lipka, Ann Arbor, MI (US);
Eric Simon, Chelsea, MI (US);
Andy D. White, Pinckney, MI (US);
Kim M. Hutchings, Dexter, MI (US);
Xinmin Gan, Ann Arbor, MI (US);
TSRL, Inc., Ann Arbor, MI (US);
Regents of the University of Michigan, Ann Arbor, MI (US);
Abstract
Provided are prodrugs of various therapeutic agents that provide enhanced bioavailability of the therapeutic agent, and methods of treatment conditions in a subject by administration of the one or prodrugs. As provided herein a prodrug includes a therapeutic agent covalently attached to a cap, the cap having a structure according to formula (I) where: Ris a branched or linear substituted or unsubstituted C2-C6 alkyl, alkenyl, or alkynl; X is —S(0)-; Ris a branched or linear substituted or unsubstituted C4-C20 alkyl, alkenyl, or alkynyl; and Ris —H, C3-C5 cycloalkyl, C3-C5 cycloheteroalkyl, —C(CH), —CF, —C(CF), or a substituted or unsubstituted phenyl.