The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 26, 2025
Filed:
Jan. 13, 2022
Applicant:
Memorial Sloan Kettering Cancer Center, New York, NY (US);
Inventors:
Liang Deng, New York, NY (US);
Jedd Wolchok, New York, NY (US);
Taha Merghoub, New York, NY (US);
Stewart Shuman, New York, NY (US);
Peihong Dai, New York, NY (US);
Weiyi Wang, New York, NY (US);
Assignee:
MEMORIAL SLOAN KETTERING CANCER CENTER, New York, NY (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/768 (2015.01); A61K 39/12 (2006.01); A61K 39/395 (2006.01); C07K 16/28 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 35/768 (2013.01); A61K 39/12 (2013.01); A61K 39/3955 (2013.01); C07K 16/2818 (2013.01); C07K 16/2827 (2013.01); A61K 2039/505 (2013.01); A61K 2039/525 (2013.01); A61K 2039/5254 (2013.01); A61K 2039/54 (2013.01); A61K 2039/545 (2013.01); A61K 2039/57 (2013.01); C12N 2710/24122 (2013.01); C12N 2710/24132 (2013.01); C12N 2710/24134 (2013.01); C12N 2710/24171 (2013.01);
Abstract
The present disclosure relates to modified vaccinia Ankara (MVA) virus or MVAΔE3L delivered intratumorally or systemically as an anticancer immunotherapeutic agent, alone, or in combination with one or more immune checkpoint blocking agents for the treatment of malignant solid tumors. Particular embodiments relate to mobilizing the host's immune system to mount an immune response against the tumor.