The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 26, 2025
Filed:
Aug. 06, 2021
Modulation of the gut microbiome to treat mental disorders or diseases of the central nervous system
Applicant:
Holobiome, Inc., South Boston, MA (US);
Inventors:
Philip Strandwitz, Medford, MA (US);
Kim Lewis, Newton, MA (US);
Assignee:
Holobiome, Inc., Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/742 (2015.01); A61K 35/74 (2015.01); A61K 35/745 (2015.01); A61P 25/18 (2006.01); A61P 25/22 (2006.01); A61P 25/24 (2006.01); C12N 9/02 (2006.01); C12N 9/10 (2006.01); C12N 9/78 (2006.01); C12N 9/88 (2006.01);
U.S. Cl.
CPC ...
A61K 35/742 (2013.01); A61K 35/74 (2013.01); A61K 35/745 (2013.01); A61P 25/18 (2018.01); A61P 25/22 (2018.01); A61P 25/24 (2018.01); C12N 9/0008 (2013.01); C12N 9/0069 (2013.01); C12N 9/1096 (2013.01); C12N 9/78 (2013.01); C12N 9/88 (2013.01); C12Y 102/01019 (2013.01); C12Y 113/12001 (2013.01); C12Y 206/01082 (2013.01); C12Y 305/03011 (2013.01); C12Y 401/01015 (2013.01); C12Y 401/01017 (2013.01); Y02A 50/30 (2018.01);
Abstract
The present disclosure relates to methods of treating at least one symptom of a mental disorder or disease of the central nervous system in a subject by modulating the amount of GABA produced in the subject's gut. The present disclosure also relates to methods of culturing the bacterial strain new bacterial strains. Also disclosed are methods of identifying bacterial strains capable of producing GABA, and engineering strains to produce GABA.