The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 26, 2025

Filed:

Jul. 13, 2021
Applicant:

Lead Billion Limited, Kowloon Bay, HK;

Inventors:

Ming Li, Shatin, HK;

Lei Cheng, Shatin, HK;

Hong-Wei Liu, Beijing, CN;

Assignee:

Lead Billion Limited, Hong Kong, HK;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/704 (2006.01); A61K 31/192 (2006.01); A61K 31/56 (2006.01); A61K 35/34 (2015.01); C07C 62/32 (2006.01);
U.S. Cl.
CPC ...
A61K 31/704 (2013.01); A61K 31/192 (2013.01); A61K 31/56 (2013.01); A61K 35/34 (2013.01); C07C 62/32 (2013.01);
Abstract

A pharmaceutical composition and method for regenerating cardiomyocytes in treating or repairing heart muscle damages cause by an ischemic disease. The pharmaceutical composition contains an active ingredient compound with a backbone structure of Formula (I). The active ingredient compound is capable of (a) increasing viability of myogenic precursor cells to enable said precursor cells to survive through an absolute ischemic period; (b) reconstituting a damaged blood supply network in said heart region where said injured muscle is located; and (c) enhancing cardiomyogenic differentiation efficiency of said precursor cells down cardiac linage, said steps being performed simultaneously or in any particular order.


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