The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 26, 2025

Filed:

May. 07, 2020
Applicant:

Amalive Limited, Aldridge, GB;

Inventors:

Stanley Bukofzer, Hazelwood, MO (US);

Regis Vilchez, Hazelwood, MO (US);

Assignee:

AMALIVE LIMITED, Aldridge, GB;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61P 1/16 (2006.01); A61B 5/00 (2006.01); A61K 31/192 (2006.01); A61K 31/198 (2006.01); A61K 31/235 (2006.01); A61P 25/28 (2006.01);
U.S. Cl.
CPC ...
A61B 5/4076 (2013.01); A61B 5/4244 (2013.01); A61B 5/4839 (2013.01); A61B 5/4842 (2013.01); A61K 31/192 (2013.01); A61K 31/198 (2013.01); A61K 31/235 (2013.01); A61P 1/16 (2018.01); A61P 25/28 (2018.01);
Abstract

The present disclosure relates to methods of treating or ameliorating hepatic encephalopathy (HE), including assessing the severity of HE in a patient suffering from HE, or the determining the presence or occurrence of an overt hepatic encephalopathy event. In particular, some aspects of the methods use a novel Hepatic Encephalopathy Staging Tool (HEST), which includes a set of criteria to categorize the HE into different stages and provide guidance on effective treatments based on the severity of the HE. Other aspects of the methods use an Overt Hepatic Encephalopathy Screening Tool (O-HEST) to determine whether an OHE event is occurring or has occurred and provide guidance on proper medical attention and change in treatment.


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