The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 19, 2025

Filed:

Jun. 01, 2020
Applicant:

City University of Hong Kong, Kowloon, HK;

Inventors:

Youngjin Lee, Seoul, KR;

Abhimanyu Thakur, West Bengal, IN;

Chi-Man Lawrence Wu, Kowloon, HK;

Guangyu Qiu, Zurich, CH;

Chen Xu, Nantong, CN;

Siu-Pang Ng, Kowloon, HK;

Tian Yang, New Territories, HK;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/574 (2006.01); B82Y 5/00 (2011.01); G01Q 60/24 (2010.01); G01N 33/543 (2006.01);
U.S. Cl.
CPC ...
G01N 33/57407 (2013.01); B82Y 5/00 (2013.01); G01Q 60/24 (2013.01);
Abstract

A method of detecting one or more exosomal protein in a sample includes the steps of: a) introducing the sample on at least a part of a first sensor having a nanostructure thereon, subjecting the first sensor to an optical radiation in a certain spectral range to produce a localized surface plasmon resonance and measuring an induced phase response; and b) introducing the sample on a second sensor having a nanostructure thereon, and obtaining an image via atomic force microscopy analysis with a probe functionalized with an antibody targeting the exosomal protein. A kit for detecting at least one exosomal protein in a sample includes a first sensor having a nanostructure thereon; a second sensor having a nanostructure thereon, and a probe functionalized with an antibody targeting the exosomal protein.


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