The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 19, 2025
Filed:
Jan. 22, 2024
Epigenetic markers and related methods and means for the detection and management of certain cancers
Eurofins Genomics Europe Sequencing Gmbh, Constance, DE;
Genedata Ag, Basel, CH;
Ucl Business Ltd., London, GB;
Martin Widschwendter, Wildermieming, AT;
Allison Jones, London, GB;
Iona Evans, London, GB;
Harri Lempiäinen, Binningen, CH;
Johannes Eichner, Lörrach, DE;
Tamas Rujan, Oberwil, CH;
Timo Wittenberger, Constance, DE;
Tobias Paprotka, Leipzig, DE;
Benjamin Lindner, Laupheim, DE;
Eurofins Genomics Europe Sequencing GmbH, Constance, DE;
Genedata AG, Basel, CH;
UCL Business Ltd., London, GB;
Abstract
The present invention relates to methods of determining the presence or absence of certain cancers in a human individual, as well as to related methods to determine the response to therapy against certain cancers in a human individual, in particular ovarian cancer in a woman. Such methods are based on the detection—from (eg cell-free) DNA of said human individual—of one or more methylated (or un-methylated) CpGs being associated with differentially methylated regions (DMRs) of the present invention; such as methylation (or un-methylation) at one or more or all of certain CpGs being associated with such DMRs. Accordingly, such methods have diagnostic, prognostic and/or predictive utility for detecting or managing certain cancers in women or men, in particular ovarian cancer in women. The present invention further relates to nucleic acids comprising certain sequences that may be detected during the method, or nucleic acids (such as probes and/or primers) that are useful to detect such sequences, as wells as compositions, kits, computer program products and other aspects that are useful for or related to the practice or application of such methods.