The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 19, 2025

Filed:

Apr. 30, 2020
Applicant:

The Penn State Research Foundation, University Park, PA (US);

Inventors:

Jason Laurence Rasgon, State College, PA (US);

Duverney De Jesus Chaverra Rodriguez, State College, PA (US);

Grant Leslie Hughes, Wirral, GB;

Chan Chin Heu, Bellefonte, PA (US);

Assignee:

THE PENN STATE RESEARCH FOUNDATION, University Park, PA;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 15/90 (2006.01); A01K 67/68 (2025.01); C07K 14/435 (2006.01); C12N 9/22 (2006.01);
U.S. Cl.
CPC ...
C12N 15/902 (2013.01); A01K 67/68 (2025.01); C12N 9/22 (2013.01); A01K 2217/072 (2013.01); A01K 2227/706 (2013.01); C07K 14/43581 (2013.01); C12N 2310/20 (2017.05); Y02A 50/30 (2018.01);
Abstract

Methods of targeting a molecule of interest to the oocyte of an animal are shown. In an embodiment the method utilizes a receptor binding region of a yolk protein precursor. In embodiment the yolk protein precursor is a YP1 sequence, functional fragment of functional variant thereof. The targeting molecule is linked to the molecule of interest. The molecule of interest may be a molecule of a gene editing system, such as CRISPR/Cas and in an embodiment comprises Cas. The methods and composition are useful for targeting a molecule of interest to an animal, such as an invertebrate or insect.


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