The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 19, 2025
Filed:
May. 31, 2023
Applicant:
The Wistar Institute, Philadelphia, PA (US);
Inventors:
Hildegund C. J. Ertl, Villanova, PA (US);
Xiang Yang Zhou, North Wales, PA (US);
Assignee:
The Wistar Institute, Philadelphia, PA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/86 (2006.01); A61K 39/21 (2006.01); C12N 15/861 (2006.01); A61K 39/00 (2006.01); A61K 39/015 (2006.01); A61K 39/04 (2006.01); A61K 39/29 (2006.01);
U.S. Cl.
CPC ...
C12N 15/86 (2013.01); A61K 39/21 (2013.01); C12N 15/861 (2013.01); A61K 39/015 (2013.01); A61K 39/04 (2013.01); A61K 39/29 (2013.01); A61K 2039/5256 (2013.01); C12N 2710/10043 (2013.01); C12N 2710/10343 (2013.01); C12N 2710/10352 (2013.01); C12N 2740/16134 (2013.01); C12N 2800/24 (2013.01);
Abstract
This disclosure provides replication-incompetent adenoviral vectors useful in vaccine development and gene therapy. The disclosed vectors comprise a selective deletion of E3 and are particularly useful for preparation of vaccines development and for gene therapy using toxic transgene products that result in vector instability that occurs when the entire E3 domain is deleted.