The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 19, 2025
Filed:
Aug. 31, 2020
Applicant:
Cornell University, Ithaca, NY (US);
Inventors:
Samie R. Jaffrey, New York, NY (US);
Jiahui Wu, New York, NY (US);
Assignee:
CORNELL UNIVERSITY, Ithaca, NY (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 15/62 (2006.01); A61K 31/7105 (2006.01); C07K 19/00 (2006.01); C12N 5/071 (2010.01); C12N 9/02 (2006.01); C12N 15/115 (2010.01); C12N 15/52 (2006.01); C12N 15/85 (2006.01); C12Q 1/6816 (2018.01);
U.S. Cl.
CPC ...
C12N 15/62 (2013.01); C12N 5/0602 (2013.01); C12N 15/115 (2013.01); C12N 15/52 (2013.01); C12N 15/85 (2013.01); C12Q 1/6816 (2013.01); C12Y 111/01011 (2013.01); C12Y 113/12013 (2013.01); C12Y 201/01043 (2013.01); C12Y 603/0401 (2013.01); C07K 2319/60 (2013.01); C07K 2319/61 (2013.01); C07K 2319/85 (2013.01); C12N 2310/16 (2013.01); C12N 2800/107 (2013.01);
Abstract
The present disclosure is directed to RNA-regulated fusion proteins comprising a protein of interest and an RNA-regulated destabilization domain. Also disclosed are RNA aptamers that bind specifically to a RNA-regulated destabilization domain. Nucleic acid molecules encoding the RNA-regulated fusion proteins and RNA aptamers and methods of use thereof are also disclosed.