The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 19, 2025

Filed:

Dec. 29, 2022
Applicant:

Bar-ilan University, Ramat Gan, IL;

Inventors:

Jean-Paul Lellouche, Ashdod, IL;

Shulamit Michaeli, Kiryat Ono, IL;

Limor Liron Israel, Modiin, IL;

Emmanuel Lellouche, Ramat Gan, IL;

Yekaterina Kapilov-Buchman, Ramat Gan, IL;

Assignee:

Bar-Ilan University, Ramat Gan, IL;

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01); A61K 9/50 (2006.01); A61K 9/51 (2006.01); A61K 31/7088 (2006.01); A61K 33/26 (2006.01); A61K 47/52 (2017.01); A61K 47/59 (2017.01); A61K 47/69 (2017.01); B01J 13/02 (2006.01); B82Y 5/00 (2011.01); B82Y 40/00 (2011.01); C01G 49/06 (2006.01); C12N 15/11 (2006.01); C12N 15/87 (2006.01); B82Y 15/00 (2011.01); B82Y 30/00 (2011.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); A61K 9/5115 (2013.01); A61K 31/7088 (2013.01); A61K 33/26 (2013.01); A61K 47/52 (2017.08); A61K 47/59 (2017.08); A61K 47/6923 (2017.08); A61K 47/6929 (2017.08); B01J 13/02 (2013.01); B82Y 5/00 (2013.01); C01G 49/06 (2013.01); C12N 15/111 (2013.01); A61K 9/5094 (2013.01); B82Y 15/00 (2013.01); B82Y 30/00 (2013.01); B82Y 40/00 (2013.01); C01P 2002/54 (2013.01); C01P 2002/72 (2013.01); C01P 2002/82 (2013.01); C01P 2002/85 (2013.01); C01P 2002/88 (2013.01); C01P 2004/04 (2013.01); C12N 15/87 (2013.01); C12N 2310/113 (2013.01); C12N 2310/14 (2013.01); C12N 2310/141 (2013.01); C12N 2310/351 (2013.01); C12N 2320/32 (2013.01);
Abstract

A nanoparticle, which has a metal oxide core and a cerium shell is provided. The weight ratio of the cerium within the shell to the metal oxide in the core is at least 1%. Additionally a method for delivering a ligand into a cell with the nanoparticle is provided. Processes for making the nanoparticle which include: sonicating an aqueous composition containing Ceric Ammonium Nitrate and a prefabricated nano particle suspension; and (b) adding a polycationic polymer to the mixture (for NP surface functionalization), are also described.


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