The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 19, 2025

Filed:

Jun. 08, 2022
Applicant:

Creative Medical Technologies, Inc., Phoenix, AZ (US);

Inventors:

Thomas Ichim, San Diego, CA (US);

Amit Patel, Salt Lake City, UT (US);

Assignee:
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/0775 (2010.01); A61K 40/10 (2025.01); A61K 40/22 (2025.01); A61K 40/41 (2025.01); A61L 27/38 (2006.01); A61P 3/10 (2006.01); C12N 5/078 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0662 (2013.01); A61K 40/10 (2025.01); A61K 40/22 (2025.01); A61K 40/416 (2025.01); A61L 27/3834 (2013.01); A61P 3/10 (2018.01); C12N 5/0634 (2013.01); A61K 2239/31 (2023.05); A61K 2239/38 (2023.05);
Abstract

Disclosed are means, methods and compositions of matter useful for prevention and/or reversion of type 1 diabetes by upregulation of myeloid suppressor cell activity in a mammal suffering from and/or at risk of developing type 1 diabetes. In one embodiment the invention teaches administration of immune cells that have been conditioned by exposure to regenerative cells, and/or cultured in the presence of factors produced from regenerative cells. In one embodiment said regenerative cells are umbilical cord derived mesenchymal stem cells. In one embodiment, immune cells that have been exposed to said regenerative cells are administered together with agents known to enhance myeloid suppressor cell activity. In another embodiment immune cells are administered together with exogenous myeloid suppressor cells.


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