The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 19, 2025
Filed:
Oct. 24, 2022
Applicant:
Technion Research & Development Foundation Limited, Haifa, IL;
Inventors:
Michal Amit, Yuvalim, IL;
Joseph Itskovitz-Eldor, Haifa, IL;
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/074 (2010.01); C12N 5/00 (2006.01); C12N 5/071 (2010.01); C12N 5/073 (2010.01); C12N 5/0735 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0606 (2013.01); C12N 5/0018 (2013.01); C12N 5/0037 (2013.01); C12N 5/0043 (2013.01); C12N 5/0056 (2013.01); C12N 5/0602 (2013.01); C12N 5/0603 (2013.01); C12N 2500/90 (2013.01); C12N 2500/98 (2013.01); C12N 2501/115 (2013.01); C12N 2501/15 (2013.01); C12N 2501/23 (2013.01); C12N 2501/2306 (2013.01); C12N 2506/02 (2013.01); C12N 2533/52 (2013.01);
Abstract
Well-defined, xeno-free culture media which comprise a TGF-beta isoform or the chimera formed between IL6 and the soluble IL6 receptor (IL6RIL6), which are capable of maintaining stem cells, and particularly, human embryonic stem cells, in an undifferentiated state are provided. Also provided are cell cultures comprising the culture media and the stem cells and methods of expanding and deriving embryonic stem cells in such well-defined, xeno-free culture media. In addition, the present invention provides methods of differentiating ESCs or EBs formed therefrom for the generation of lineage specific cells.