The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 19, 2025
Filed:
Sep. 03, 2021
Hoffmann-la Roche Inc., Little Falls, NJ (US);
Laura Codarri-Deak, Schlieren, CH;
Georg Fertig, Penzberg, DE;
Jens Fischer, Penzberg, DE;
Christian Klein, Schlieren, CH;
Viktor Levitski, Schlieren, CH;
Valeria Lifke, Penzberg, DE;
Mario Perro, Schlieren, CH;
Joerg Thomas Regula, Penzberg, DE;
Tilman Schlothauer, Basel, DE;
Stefan Seeber, Penzberg, DE;
Pablo Umana, Penzberg, CH;
Ildiko Wuensche, Penzberg, DE;
Adrian Zwick, Penzberg, DE;
Hoffmann-La Roche Inc., Little Falls, NJ (US);
Abstract
The invention relates to bispecific antibodies comprising a first antigen-binding site that specifically binds to PD1 and a second antigen-binding site that specifically binds to TIM3, in particular to bispecific antibodies, wherein the bispecific antibody binds to 5 TIM3 with a lower binding affinity when compared to the binding to PD1. The invention further relates to methods of producing these molecules and to methods of using the same.