The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 19, 2025
Filed:
Jun. 22, 2017
Applicants:
Vincent C. O. Njar, Glen Burnie, MD (US);
Purushottamachar Puranik, Gaithersburg, MD (US);
Francis Murigi, Germantown, MD (US);
Inventors:
Vincent C. O. Njar, Glen Burnie, MD (US);
Purushottamachar Puranik, Gaithersburg, MD (US);
Francis Murigi, Germantown, MD (US);
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07J 75/00 (2006.01); A61K 31/58 (2006.01); C07J 43/00 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
C07J 43/003 (2013.01); A61K 31/58 (2013.01); A61P 35/00 (2018.01);
Abstract
Galeterone and its C-3 analogs are of substantial interest because of their multi-target anticancer activities, including AR and Mnk degrading activities. Provided are novel procedures for gram-scale, high-yield synthesis of C-3 analogs of galeterone, including 3β-(1H-imidazole-1-yl)-17-(1H-benzimidazole-1-yl)-androsta-5,16-diene (galeterone 3β-imidazole) and 3β-(pyridine-4-ylmethoxy)-17-(1H-benzimidazol-1-yl)androsta-5,16-diene (galeterone 3β-pyridine methoxylate).