The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 19, 2025
Filed:
Dec. 18, 2019
Applicant:
Shy Therapeutics, Llc, Harrison, NY (US);
Inventors:
Yaron R. Hadari, Harrison, NY (US);
Michael Schmertzler, St. Petersburg, FL (US);
Theresa M. Williams, Harleysville, PA (US);
Luca Carta, Scarsdale, NY (US);
Rebecca Hutcheson, Stamford, CT (US);
Charles H. Reynolds, Austin, TX (US);
Assignee:
SHY Therapeutics, LLC, Harrison, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 495/04 (2006.01); A61P 35/00 (2006.01); C07D 401/04 (2006.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01); C07D 403/14 (2006.01); C07D 519/00 (2006.01);
U.S. Cl.
CPC ...
C07D 495/04 (2013.01); A61P 35/00 (2018.01); C07D 401/04 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 403/14 (2013.01); C07D 519/00 (2013.01);
Abstract
Provided herein are methods and compositions for treating cancers, inflammatory diseases, rasopathies, and fibrotic disease involving aberrant Ras superfamily signaling through the binding of compounds to the GTP binding domain of Ras superfamily proteins including, in certain cases, K-Ras and mutants thereof, and a method for assaying such compositions.