The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 19, 2025
Filed:
Mar. 23, 2021
Applicant:
Wigen Biomedicine Technology (Shanghai) Co., Ltd., Shanghai, CN;
Inventors:
Yuli Xie, Shanghai, CN;
Houxing Fan, Shanghai, CN;
Gang Cao, Shanghai, CN;
Lihui Qian, Shanghai, CN;
Assignee:
WIGEN BOIMEDICINE TECHNOLOGY (SHANGHAI) CO., LTD., Shanghai, CN;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 239/72 (2006.01); A61K 31/517 (2006.01); A61P 35/00 (2006.01); C07D 471/10 (2006.01); C07D 519/00 (2006.01);
U.S. Cl.
CPC ...
C07D 471/10 (2013.01); A61P 35/00 (2018.01); C07D 519/00 (2013.01); C07B 2200/07 (2013.01); C07B 2200/13 (2013.01);
Abstract
The present invention relates to a compound of general formula (1) and a preparation method therefor, and use of the compound of formula (1) and isomers, crystalline forms and pharmaceutically acceptable salts thereof as an irreversible inhibitor for a K-Ras G12C mutant protein in preparing a medicament for resisting Ras-related diseases such as tumors.