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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12391660 B1

PDFFull Text
Date of Patent:
Aug. 19, 2025

Filed:

May. 29, 2020

Heteroaromatic acetamide derivative, and preparation and use thereof

Applicant:

Hangzhou Westan Pharmaceutical Technology Co., Ltd, Zhejiang, CN;

Inventors:

Yunfeng Cheng, Zhejiang, CN;

Yongzhou Hu, Zhejiang, CN;

Assignee:

HANGZHOU WESTAN PHARMACEUTICAL TECHNOLOGY CO., LTD, Zhejiang, CN;

Attorney:

Scully, Scott, Murphy & Presser, P.C.

Primary Examiner:

Jeffrey H Murray

Assistant Examiner:

Madeline E Braun

Int. Cl.
CPC ...
C07D 295/185 (2006.01); A61P 11/06 (2006.01); C07D 211/16 (2006.01); C07D 221/20 (2006.01); C07D 401/04 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01); C07D 403/06 (2006.01); C07D 405/06 (2006.01); C07D 405/14 (2006.01); C07D 409/04 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 417/04 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01); C07D 471/08 (2006.01);
U.S. Cl.
CPC ...
C07D 295/185 (2013.01); A61P 11/06 (2018.01); C07D 211/16 (2013.01); C07D 221/20 (2013.01); C07D 401/04 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 403/06 (2013.01); C07D 405/06 (2013.01); C07D 405/14 (2013.01); C07D 409/04 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/04 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01); C07D 471/08 (2013.01);
Abstract

Provided in the present invention are a heteroaromatic acetamide derivative and the preparation and the use thereof, wherein the heteroaromatic acetamide derivative is a heteroaromatic acetamide compound as shown in general formula (I), or a pharmaceutically acceptable salt and/or solvate thereof. According to the present invention, experiments have confirmed that the heteroaromatic acetamide derivative of the present invention can specifically bind to transient receptor potential ankyrin 1 (TRPA1) and inhibit or reduce the activity thereof, and can be used for treating diseases mediated by TRPA1. The present invention further provides a method for preparing the heteroaromatic acetamide derivative, and a drug and pharmaceutical composition containing the heteroaromatic acetamide derivative.

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