The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 19, 2025
Filed:
May. 19, 2020
Applicant:
University of Massachusetts, Westborough, MA (US);
Inventors:
Guangping Gao, Worcester, MA (US);
Hemant Khanna, Worcester, MA (US);
Assignee:
University of Massachusetts, Westborough, MA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); A61K 35/76 (2015.01); A61P 27/02 (2006.01); C07K 14/705 (2006.01); C12N 5/079 (2010.01); C12N 7/00 (2006.01); C12N 15/113 (2010.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
A61K 48/0058 (2013.01); A61K 35/76 (2013.01); A61P 27/02 (2018.01); C07K 14/705 (2013.01); C12N 5/0621 (2013.01); C12N 7/00 (2013.01); C12N 15/113 (2013.01); C12N 15/86 (2013.01); C12N 2310/10 (2013.01); C12N 2750/14122 (2013.01); C12N 2750/14142 (2013.01); C12N 2830/008 (2013.01);
Abstract
Aspects of the disclosure relate to compositions and methods useful for treating ocular ciliopathies, for example Leber congenital amaurosis (LCA). In some embodiments, the disclosure provides isolated nucleic acids comprising a transgene encoding a CEP290 protein fragment, and methods of treating ocular ciliopathies using the same.