The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 19, 2025
Filed:
Aug. 25, 2022
Applicant:
Kathleen E. Clarence-smith, Washington, DC (US);
Inventor:
Kathleen E. Clarence-Smith, Washington, DC (US);
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4425 (2006.01); A61K 31/24 (2006.01); A61K 31/407 (2006.01); A61K 31/4178 (2006.01); A61K 31/438 (2006.01); A61K 31/5377 (2006.01); A61P 1/08 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4425 (2013.01); A61K 31/24 (2013.01); A61K 31/407 (2013.01); A61K 31/4178 (2013.01); A61K 31/438 (2013.01); A61K 31/5377 (2013.01); A61P 1/08 (2018.01);
Abstract
The present invention relates to compositions comprising an antiemetic, particularly including 5-HT3 antagonist and/or NK-1 antagonist antiemetics, in combination with a choline esterase inhibitor such as an acetylcholine esterase inhibitor and/or a butyrylcholine esterase inhibitor, and methods of using the composition to provide improved protection of subjects at risk of organophosphorus poisoning, or, for the treatment, prevention, or alleviation/reduction of toxicity from an organophosphorus compound, by enabling the use of a highly protective daily dose of the choline esterase inhibitor without the typical adverse effects.