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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12390443 B1

PDFFull Text
Date of Patent:
Aug. 19, 2025

Filed:

Feb. 18, 2022

Applications of butyrolactone-i in preparing medicine for preventing neuroinflammation and/or memory and cognitive disorders

Applicants:

Guangdong Ocean University, Zhanjiang, CN;

Shenzhen Institute of Guangdong Ocean University, Shenzhen, CN;

Inventors:

Yi Zhang, Zhanjiang, CN;

Yingying Nie, Shenzhen, CN;

Yayue Liu, Zhanjiang, CN;

Xiaoxiang Ma, Dongguan, CN;

Jinyue Liang, Yunfu, CN;

Yanmei Li, Zhaoqing, CN;

Yuan Wang, Dongguan, CN;

Zhiyou Yang, Zhanjiang, CN;

Yongping Zhang, Zhanjiang, CN;

Cai Song, Shenzhen, CN;

Pengzhi Hong, Zhanjiang, CN;

Zhongji Qian, Zhanjiang, CN;

Assignees:

GUANDONG OCEAN UNIVERSITY, Zhanjiang, CN;

SHENZHEN INSTITUTE OF GUANGDONG OCEAN UNIVERSITY, Shenzhen, CN;

Attorney:

Cooper Legal Group, LLC

Primary Examiner:

Jeffrey H Murray

Assistant Examiner:

Daniel John Burkett

Int. Cl.
CPC ...
A61K 31/365 (2006.01); A61P 25/28 (2006.01);
U.S. Cl.
CPC ...
A61K 31/365 (2013.01); A61P 25/28 (2018.01);
Abstract

Applications of butyrolactone-I in preparation of medicine for preventing aluminum-induced neuroinflammation and/or memory and cognitive disorder in zebrafish are provided. The applications have proven that at the animal level, butyrolactone-I may prevent aluminum-induced neuroinflammation and improve memory and cognitive disorder through the targets of antioxidation-inhibition of acetylcholinesterase activity-antiinflammation-regulation of intestinal flora disorder, and that butyrolactone-I may be used to prepare medicine for preventing aluminum-induced neuroinflammation and/or improving memory and cognitive disorder, thus providing a feasible scheme for preventing neurodegenerative diseases in clinical medicine.

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Zhang, Yi. (2025). Applications of butyrolactone-i in preparing medicine for preventing neuroinflammation and/or memory and cognitive disorders (U.S. Patent No. 12390443). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12390443

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