The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 19, 2025

Filed:

Apr. 16, 2020
Applicants:

Quing Zhu, St. Louis, MO (US);

Shiqi Xu, Durham, NC (US);

Inventors:

Quing Zhu, St. Louis, MO (US);

Shiqi Xu, Durham, NC (US);

Assignee:

Washington University, St. Louis, MO (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61B 5/00 (2006.01); A61B 8/00 (2006.01); A61B 8/08 (2006.01);
U.S. Cl.
CPC ...
A61B 5/4312 (2013.01); A61B 5/0035 (2013.01); A61B 5/0091 (2013.01); A61B 8/0825 (2013.01); A61B 8/4416 (2013.01);
Abstract

A diffuse optical tomography (DOT) system for generating a functional image of a lesion region of a subject includes a source subsystem configured to generate optical waves, a probe coupled to the source subsystem and configured to emit the optical waves generated by the source subsystem toward the lesion region and to detect optical waves reflected by the lesion region, a detection subsystem configured to convert the optical waves detected by the probe to digital signals, and a computing device including a processor and a memory. The memory includes instructions that program the processor to receive the digital signals sent from the detection subsystem, calculate an initial estimate of the functional image by solving an inverse optimization problem with a shape-regularized Fast Iterative Shrinkage-Thresholding algorithm (FISTA), reconstruct the functional image iteratively using a Finite Difference Method (FDM) or a Finite Element Method (FEM), and display the functional image.


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