Brain functional connectivity correlation value adjustment method, brain functional connectivity correlation value adjustment system, brain activity classifier harmonization method, brain activity classifier harmonization system, and brain activity biomarker system

Abstract

A harmonization system for a brain activity classifier harmonizing brain measurement data obtained at a plurality of sites to realize a discrimination process based on brain functional imaging: obtains data, for a plurality of traveling subjects as common objects of measurements at each of the plurality of measurement sites, resulting from measurements of brain activities of a predetermined plurality of brain regions of each of the traveling subjects; calculates, for each of the traveling subjects, prescribed elements of a brain functional connectivity matrix representing the temporal correlation of brain activities of a set of the plurality of brain regions; using a generalized linear mixed model, calculates measurement bias datafor each element of the brain functional connectivity matrix, as a fixed effect at each measurement site with respect to an average of the corresponding element across the plurality of measurement sites and across the plurality of traveling subjects; and thereby executes a harmonizing process.