The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 12, 2025

Filed:

Dec. 26, 2019
Applicant:

The General Hospital Corporation, Boston, MA (US);

Inventors:

Jon F. Edd, Wakefield, MA (US);

Kaja Kaastrup, Charlestown, MA (US);

Ravi Kapur, Sharon, MA (US);

Mehmet Toner, Charlestown, MA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/543 (2006.01); B01L 3/00 (2006.01); G01N 33/49 (2006.01);
U.S. Cl.
CPC ...
G01N 33/54366 (2013.01); B01L 3/502761 (2013.01); G01N 33/491 (2013.01); G01N 33/54313 (2013.01); B01L 2200/0652 (2013.01); B01L 2300/0636 (2013.01); B01L 2300/0816 (2013.01); B01L 2400/086 (2013.01);
Abstract

Methods of using particle size amplification to facilitate size-based particle separation and concentration. At least one of the methods includes introducing a plurality of binding moieties into a fluid sample; allowing at least one of the binding moieties to bind two or more biological particles to form a particle cluster, in which the particle cluster includes a first type of biological particle bound to a second different type of biological particle; and flowing the fluid sample including the particle cluster into a particle sorting region of a microfluidic device.


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