The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 12, 2025

Filed:

Aug. 20, 2021
Applicants:

Universiteit Gent, Ghent, BE;

Universiteit Antwerpen, Antwerp, BE;

Imec Vzw, Leuven, BE;

Inventors:

Wouter Van Putte, Diksmuide, BE;

Thomas Reichert, Ostend, BE;

Jean-Pierre Timmermans, Mol, BE;

Assignees:

UNIVERSITEIT GENT, Ghent, BE;

UNIVERSITEIT ANTWERPEN, Antwerp, BE;

IMEC VZW, Leuven, BE;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 1/28 (2006.01); G01N 1/42 (2006.01); G01N 23/2204 (2018.01);
U.S. Cl.
CPC ...
G01N 1/2813 (2013.01); G01N 1/42 (2013.01); G01N 23/2204 (2013.01); G01N 2001/2826 (2013.01); G01N 2223/418 (2013.01);
Abstract

The invention provides in an electron microscopy grid, comprising: a perforated substrate; a support film on the perforated substrate; a mixture of different linker molecules according to Structure (I), wherein AG is an anchoring group, for anchoring the linker molecule to the solid support; BU is a binding unit, for binding to the analyte; L1 is a first linear linker section; Lis a second linear linker section; α is the angle between the linear linker section Land the linear linker section L; AS is an angled linker section, connecting the linear linker section Land the linear linker section L. The invention further provides in method of structural determination of analytes, using such EM-grids.


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