The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 12, 2025
Filed:
Feb. 14, 2022
Astellas Pharma Inc., Tokyo, JP;
Tomohiro Yoshinari, Tokyo, JP;
Hiroki Ishioka, Tokyo, JP;
Eiji Kawaminami, Tokyo, JP;
Hideyuki Watanabe, Tokyo, JP;
Kenichi Kawaguchi, Tokyo, JP;
Kazuyuki Kuramoto, Tokyo, JP;
Tomoyoshi Imaizumi, Tokyo, JP;
Takahiro Morikawa, Tokyo, JP;
Hisao Hamaguchi, Tokyo, JP;
Sunao Imada, Tokyo, JP;
Mitsuaki Okumura, Tokyo, JP;
Takeyuki Nagashima, Tokyo, JP;
Kohei Inamura, Tokyo, JP;
Astellas Pharma Inc., Tokyo, JP;
Abstract
[Problem] To provide a compound useful as an active ingredient of a pharmaceutical composition for treating pancreatic cancer. [Means for resolution] The present inventors have studied about a compound that is useful as an active ingredient of a pharmaceutical composition for treating pancreatic cancer and have found that a quinazoline compound has an excellent degradation-inducing action on a G12D mutant KRAS protein and a G12D mutant KRAS inhibition activity and can be used as a therapeutic agent for pancreatic cancer, thus completing the present invention. The quinazoline compound or a salt thereof of the present invention can be used as a therapeutic agent for pancreatic cancer.