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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12384741 B1

PDFFull Text
Date of Patent:
Aug. 12, 2025

Filed:

Nov. 03, 2023

Lipid nanoparticle compositions for delivering circular polynucleotides

Applicant:

Orna Therapeutics, Inc., Watertown, MA (US);

Inventors:

Allen T. Horhota, Cambridge, MA (US);

Junghoon Yang, Cambridge, MA (US);

Kevin Kauffman, Newton, MA (US);

Thomas Barnes, Cambridge, MA (US);

Robert Alexander Wesselhoeft, Cambridge, MA (US);

Amy M. Becker, Cambridge, MA (US);

Gregory Motz, Cambridge, MA (US);

Assignee:

Orna Therapeutics, Inc., Watertown, MA (US);

Attorneys:

Christopher K. Haley

Carl A. Morales

Goodwin Procter LLP

Primary Examiner:

Carlos A Azpuru

Int. Cl.
CPC ...
C07C 229/12 (2006.01); A61K 9/1272 (2025.01); A61K 31/7105 (2006.01); A61K 45/06 (2006.01); A61K 47/10 (2017.01); A61K 47/18 (2017.01); A61K 47/24 (2006.01); A61K 47/28 (2006.01); A61K 47/54 (2017.01); A61K 48/00 (2006.01); C07C 219/06 (2006.01); C07C 229/22 (2006.01); C07C 229/24 (2006.01);
U.S. Cl.
CPC ...
C07C 229/12 (2013.01); A61K 9/1272 (2013.01); A61K 31/7105 (2013.01); A61K 45/06 (2013.01); A61K 47/10 (2013.01); A61K 47/18 (2013.01); A61K 47/183 (2013.01); A61K 47/24 (2013.01); A61K 47/28 (2013.01); A61K 47/543 (2017.08); A61K 48/0033 (2013.01); C07C 219/06 (2013.01); C07C 229/22 (2013.01); C07C 229/24 (2013.01);
Abstract

Disclosed herein are novel lipids that can be used in combination with other lipid components, such as helper lipids, structural lipids, and cholesterols, to form lipid nanoparticles for delivery of therapeutic agents, such as nucleic acids (e.g., circular polynucleotides), both in vitro and in vivo.

Find Patent Forward Citations

Horhota, Allen. (2025). Lipid nanoparticle compositions for delivering circular polynucleotides (U.S. Patent No. 12384741). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12384741

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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