The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 12, 2025

Filed:

May. 31, 2019
Applicant:

The George Washington University, Washington, DC (US);

Inventors:

Dayun Yan, Ashburn, VA (US);

Michael Keidar, Baltimore, MD (US);

Eda Gjika, Washington, DC (US);

Assignee:

George Washington University, Washington, DC (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61N 1/44 (2006.01); A61K 31/4188 (2006.01); A61K 33/40 (2006.01); A61K 41/00 (2020.01); H01J 37/32 (2006.01);
U.S. Cl.
CPC ...
A61N 1/44 (2013.01); A61K 31/4188 (2013.01); A61K 33/40 (2013.01); A61K 41/00 (2013.01); H01J 37/32366 (2013.01); H01J 37/32449 (2013.01); H01J 37/32825 (2013.01);
Abstract

A method and system of adaptive cold atmospheric based treatment for diseased tissues, such as an area with cancerous cells, is disclosed. A gas such as helium is ionized via supplying power between and anode and a cathode to create an initial cold atmospheric plasma jet. The initial plasma jet is directed toward the area for a sufficient time, such as 10 seconds, to sensitize the cells via a reactive species. A reactive treatment, such as H2O2 or TMZ, is directed to the sensitized cells. The effectiveness of the reactive treatment is increased by the process of sensitizing the cells.


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