The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 12, 2025

Filed:

Dec. 22, 2022
Applicant:

Children's Medical Center Corporation, Boston, MA (US);

Inventors:

Wayne I. Lencer, Jamaica Plain, MA (US);

Daniel J F Chinnapen, Quincy, MA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/54 (2017.01); A61K 38/22 (2006.01); A61K 38/26 (2006.01); A61K 39/00 (2006.01); A61K 39/395 (2006.01);
U.S. Cl.
CPC ...
A61K 38/26 (2013.01); A61K 38/22 (2013.01); A61K 39/00 (2013.01); A61K 39/395 (2013.01); A61K 47/54 (2017.08); A61K 47/549 (2017.08);
Abstract

Provided herein, in some aspects, are delivery vehicles comprising a glycosphingolipid and an agent to be delivered attached to the glycosphingolipid. In some embodiments, the glycosphingolipid comprises an oligosaccharide and a short chain (e.g., C0-C3) ceramide. In some embodiments, the agent to be delivered is a therapeutic agent. The glycosphingolipid is able to deliver the agent to a cell or to a cellular compartment, as well as across the musical barrier. In some embodiments, agents delivered using the glycosphingolipid described herein exhibit longer half-life, compared to agents delivered alone. Methods of delivering a therapeutic agent to a subject for treating a disease using the glycosphingolipid delivery vehicle are also provided.


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Lencer, Wayne. (2025). Short chain ceramide-based lipids and uses thereof (U.S. Patent No. 12383606). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12383606

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