The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 12, 2025
Filed:
Jun. 14, 2023
Applicants:
Massachusetts Institute of Technology, Cambridge, MA (US);
Ohio State Innovation Foundation, Columbus, OH (US);
Inventors:
Darrell J. Irvine, Arlington, MA (US);
Karl Dane Wittrup, Chestnut Hill, MA (US);
Ron Weiss, Newton, MA (US);
Yingzhong Li, Quincy, MA (US);
Noor Momin, Cambridge, MA (US);
Yizhou Dong, Dublin, OH (US);
Assignees:
Massachusetts Institute of Technology, Cambridge, MA (US);
Ohio State Innovation Foundation, Columbus, OH (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/768 (2015.01); A61K 9/00 (2006.01); A61P 35/00 (2006.01); C07K 14/54 (2006.01); C12N 7/00 (2006.01);
U.S. Cl.
CPC ...
A61K 35/768 (2013.01); A61K 9/0019 (2013.01); A61P 35/00 (2018.01); C07K 14/5434 (2013.01); C12N 7/00 (2013.01); C12N 2770/36132 (2013.01);
Abstract
The present disclosure relates to synthetic oncolytic viruses comprising a lipid nanoparticle comprising one or more types of lipid and a self-amplifying replicon RNA comprising a sequence that encodes an immunomodulatory molecule.