The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 12, 2025
Filed:
Dec. 29, 2022
Applicant:
Children's Medical Center Corporation, Boston, MA (US);
Inventors:
Debra Auguste, Briarcliff Manor, NY (US);
Marsha A. Moses, Brookline, MA (US);
Peng Guo, Natick, MA (US);
Assignee:
Children's Medical Center Corporation, Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61K 9/14 (2006.01); A61K 31/191 (2006.01); A61K 31/429 (2006.01); A61K 31/4365 (2006.01); A61K 31/4965 (2006.01); A61K 39/395 (2006.01); A61K 47/54 (2017.01); C12Q 1/6886 (2018.01); G01N 33/574 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4965 (2013.01); A61K 9/14 (2013.01); A61K 31/191 (2013.01); A61K 31/429 (2013.01); A61K 31/4365 (2013.01); A61K 47/555 (2017.08); C12Q 1/6886 (2013.01); G01N 33/57415 (2013.01); A61K 2121/00 (2013.01); C12Q 2600/158 (2013.01); G01N 2333/70525 (2013.01);
Abstract
A method of detecting triple negative breast cancer (TNBC) is provided. Overexpression of ICAM-1 is linked to an increased risk of TNBC. A composition of matter is also provided that binds an anti-ICAM˜1 antibody to a nanoparticle. The composition may be used as an imaging agent and/or a therapeutic targeting agent. A therapeutically active molecule may be bound to the composition to provide targeted therapy.