The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 12, 2025
Filed:
May. 02, 2019
Universidade DE Coimbra, Coimbra, PT;
Universidade DO Porto, Oporto, PT;
Lucilia Helena Ataide Saraiva, Oporto, PT;
Joana Oliveira Gama Soares, Oporto, PT;
Teresa Margarida Vasconcelos Dias De Pinho E Melo, Coimbra, PT;
Maria Isabel Lopes Soares, Coimbra, PT;
Helena Isabel Nogueira Ramos Rocha, Oporto, PT;
UNIVERSIDADE DE COIMBRA, Coimbra, PT;
UNIVERSIDADE DO PORTO, Oporto, PT;
Abstract
The present application relates to compounds of formula I, which are (3S)- and (3R)-6,7-bis(Hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazoles. The present application also relates to pharmaceutical compositions having the compounds and the use of these compounds in the treatment of conditions influenced by wild-type or mutant p53 forms. More specifically, these compounds represent a completely new chemical family of p53-activating agents and show a higher selectivity towards the p53-pathway compared to the reactivators of p53 currently under clinical trials. For some cancer types these compounds revealed to be more potent than the reactivators of p53 currently under clinical trials. In addition to these advantages, the presently disclosed compounds are not genotoxic and have no apparent undesirable toxic side effects.