The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 12, 2025
Filed:
Feb. 13, 2024
Applicant:
Howard University, Washington, DC (US);
Inventor:
Xinbin Gu, Washington, DC (US);
Assignee:
Howard University, Washington, DC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/343 (2006.01); A61K 31/704 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/343 (2013.01); A61K 31/704 (2013.01); A61P 35/00 (2018.01);
Abstract
The present disclosure provides methods related to treating triple-negative breast cancer (TNBC) in a mammal by administering salvianolic acid B (or a salt or solvate thereof) to promote ceramide-mediated apoptosis. In one form, the ceramide-mediated apoptosis of TNBC cells occurs by decreasing the level of one or more of glucosylceramide synthase and GM3 synthase in the subject through the use of an effective amount of salvianolic acid B. In another aspect, salvianolic acid B or its pharmaceutically acceptable salt or solvate is used as a medicament or in the manufacture of a medicament for treating TNBC.