The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 12, 2025
Filed:
Aug. 15, 2023
Guangdong University of Technology, Guangdong, CN;
GUANGDONG UNIVERSITY OF TECHNOLOGY, Guangdong, CN;
Abstract
The present invention provides a method for extracting a neuroimaging biomarker based on an interpretable ensemble three-dimensional convolutional neural network (3DCNN) to address limitations in the prior art. The present invention derives a novel neuroimaging biomarker P-score from prediction results obtained by an ensemble three-dimensional convolutional neural network model. The solution can help researchers to conduct studies on longitudinal trajectory changes of structural magnetic resonance imaging (sMRI) during the progression of Alzheimer's disease, and analyze an association of the longitudinal trajectory changes with neurodegenerative changes of Alzheimer's disease subjects. The extracted neuroimaging biomarker can provide a basis for predicting a sequence of intervention of brain regions in the neurodegenerative changes of Alzheimer's disease patients and upcoming clinical symptoms.