The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 05, 2025

Filed:

Sep. 13, 2023
Applicant:

Inivata Ltd., Cambridge, GB;

Inventors:

Vincent Plagnol, Cambridge, GB;

Tim Forshew, Stevenage, GB;

Samuel Woodhouse, Cambridge, GB;

Andrew Lawson, Waltham Cross, GB;

Matthew Smith, Cambridge, GB;

Assignee:

INIVATA LTD, Cambridge, GB;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12P 19/34 (2006.01); C12Q 1/6806 (2018.01); G06F 17/18 (2006.01); G16B 50/00 (2019.01);
U.S. Cl.
CPC ...
C12Q 1/6806 (2013.01); G06F 17/18 (2013.01); G16B 50/00 (2019.02); C12Q 2600/158 (2013.01); C12Q 2600/16 (2013.01);
Abstract

Provided herein is a method for the analysis of minimal residual disease, the method comprising obtaining multiple pairs of primers, performing a targeted multiplex amplification using the multiple pairs of primers to produce amplicons, sequencing the amplicons or an amplification product thereof, thereby generating sequence reads, calculating a score based on the minority of sequences containing identified sequence variations, and using the calculated score to determine the presence or absence of minimal residual disease in the patient.


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